Chemical Biography

Emilien completed his PhD at the Département de Chimie Moléculaire, University of Grenoble under the supervision of Pierre Yves Chavant and Véronique Blandin. Emilien’s doctoral research involved the synthesis of arylboronic esters and Pd-catalyzed direct arylation reactions.

In April 2013, Emilien joined our group on a Carl Trygger postdoctoral fellowship. His project involved a combination of catalytic C-H activation, (hetero)aryne and organoboronate chemistry. Emilien developed a new class of boryl (hetero)aryne precursors in which either the boronate or aryne reactivity can be activated selectively. The results were published in Angewandte Chemie (see right). In 2016 Emilien joined BioWorks in Uppsala and in 2017 he moved to work for Recipharm.

Conferences & Presentations

• 3rd Nordic Meeting on Organometallic Chemistry, Lund, Sweden (March 11-12, 2015) – Poster

Publications

From postdoc work with us:

6. “Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis through C-H Activation and Orthogonal Reactivity”
Johanna Larsson, Emilien Demory, Karthik Devaraj, Carina Sollert, Lukasz T. Pilarski*
Synlett. 2016, DOI: 10.1055/s-0035-1561248

5. “Boryl (Hetero)aryne Precursors as Versatile Arylation Reagents: Synthesis via C-H Activation and Orthogonal Reactivity”
Emilien Demory, Karthik Devaraj, Andreas Orthaber, Paul J. Gates, Lukasz T. Pilarski*
Angew. Chem. 2015, 127, 11931–11935
Angew. Chem. Int. Ed. 2015, 54, 11765–11769

From PhD work in Grenoble:

4. “Efficient borylation of reactive aryl halides with MPBH (4,4,6-trimethyl-1,3,2-dioxaborinane)” N. PraveenGanesh, E. Demory, C. Gamon, V. Blandin P. Y. Chavant
Synlett 2010, 2403-2406

3. “Inexpensive, multigram-scale preparation of an enantiopure cyclic nitrone via resolution at the hydroxylamine stage”
M. Thiverny, E. Demory, B. Baptiste, C. Philouze, P. Y. Chavant V. Blandin
Tetrahedron: Asym. 2011, 22, 1266-1273

2. “Noncryogenic preparation of functionalized arylboronic esters through a magnesium-iodine exchange with in situ quench”
E. Demory, V. Blandin, J. Einhorn P. Y. Chavant
Org. Process Res. Dev. 2011, 77, 710-716

1. “Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters”
E. Demory, D. Farran, B. Baptiste, P. Y. Chavant, V. Blandin
J. Org. Chem. 2012, 77, 7901-7912