Jiajie Yan

PhD Student (Honorary member from the Engman group)

Chemical biography

Jiajie obtained his B.Sc. degree in pharmacy in 2010 at Soochow University, China, and then his M.Sc. degree in medicinal chemistry at 2013 at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. Later that year, Jiajie joined the group of Prof. Lars Engman (now emeritus) as a PhD student at Uppsala University. During his PhD he worked on the development of chalcogen-based regenerable antioxidants. In October 2017, Jiajie defended his PhD and joined Prof. David Procter’s group at the University of Manchester in early 2018. Following his postdoc in Manchester, Jiajie came back to Uppsala to take up a postdoc position in the group of Prof. Henrik Ottosson, over at the Ångström laboratories.

Towards the end of his PhD Jiajie worked closely together with Jagadeesh on some novel aryne-related chemistry as part of a collaboration project between the Engman group and our own. Jiajie is therefore an honorary member of our group.

Publications

From work in the Engman group:

11. “Nitro-, Azo- and Amino Derivatives of Ebselen: Synthesis, Structure and Cytoprotective Effects
Vijay P. Singh, Jia-fei Poon, Jiajie Yan, Xi Lu, Marjam Ott, Ray Butcher, Paul Gates, Lars Engman.*
J. Org. Chem. 201682, 313-321. (PDF)

10. “Regenerable Radical-Trapping Tellurobistocopherol Antioxidants.
Jia-fei Poon, Jiajie Yan, Vijay P. Singh, Paul Gates, Lars Engman.*
J. Org. Chem. 201681, 12540-12544. (PDF)

9. “Alkyltelluro Substitution Improves the Radical-Trapping Capacity of Aromatic Amines.
Jia-fei Poon, Jiajie Yan, Vijay P. Singh, Paul Gates, Lars Engman.*
Chem. Eur. J. 201632, 12891-12903. (PDF)

8. “Multifunctional Antioxidants – Regenerable Radical-Trapping and Hydroperoxide Decomposing Ebselenols
Shailesh Kumar, Jiajie Yan, Jia-fei Poon, Vijay P. Singh, Xi Lu, Marjam Ott, Lars Engman,* Sangit Kumar.*
Angew. Chem. Int. Ed. 201655, 3729-3733 (PDF)

7. “Regenerable Thiophenolic Radical-Trapping Antioxidants
Jiajie Yan, Jia-fei Poon, Vijay P. Singh, Paul Gates, Lars Engman.*
Org. Lett. 201517, 6162-6165. (PDF)

6. “Regenerable Antioxidants – Introduction of Chalcogen Substituents into Tocopherols.”
Jia-fei Poon, Vijay P. Singh, Jiajie Yan, Lars Engman.*
Chem. Eur. J. 201521, 2447-2457. Hot paper (PDF)

5. “An Unexpected Inversion of Enantioselectivity in a Copper-Catalyzed Intramolecular Desymmetric Aryl C-N Coupling Reaction
Jiangguang Liu, Jiajie Yan, Dongguang Qin, Qian Cai.*
Synthesis201446, 1917-1923 (PDF)

4. “Pd-Catalyzed Desymmetric Intramolecular O-Arylation Reaction: Enantioselective Synthesis of (3,4-Dihydro-2H-chromen-3-yl)methanols
Wenqiang Yang, Jiajie Yan, Yan Long, Shasha Zhang, Jianguang Liu, Youlin Zeng, and Qian Cai.*
Org. Lett. 201315, 6022-6025. (PDF)

3.  “A CuAAC/Ullmann C-C Coupling Tandem Reaction: Copper-Catalyzed Reactions of Organic Azides with N-(2-Iodoaryl)-propiolamides or 2-Iodo- N-(prop-2-ynyl)-benzenamines
Qian Cai,* Jiajie Yan, Ke Ding.
Org. Lett. 201214, 3332-3335. (PDF) (Highlighted by Synfacts, 2012, 8, 1020)

2. “Synthesis of [1,2,3]Triazolo-[1,5-a]quinoxalin-4(5H)-ones through Copper-Catalyzed Tandem Reactions of N-(2-Haloaryl)propiolamides with Sodium Azide
Jiajie Yan, Fengtao Zhou, Dongguang Qin, Tong Cai, Ke Ding,* Qian Cai.*
Org. Lett. 201214, 1262-1265. (PDF) (Highlighted by Synfacts, 2012, 6, 602)

1. “Structure – Activity Study on a Series of α- Glutamic Acid Scaffold Based Compounds as New ADAMTS Inhibitors
Lijie Peng, Lei Duan, Xiaofeng Liu, Mengjie Shen, Yingjun Li, Jiajie Yan, Honglin Li, Ke Ding.*
Bioorg. Med. Chem. Lett. 201121, 4457-4461 (PDF)

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